Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal brain imaging approach and demonstrated that psilocybin (0.17 mg/kg) induced region-dependent alterations in glutamate, which predicted distortions in the subjective experience of one’s self (ego dissolution). 


Seems reduced activity in the default mode network correlates with increased ego dissolution. Interestingly, both regular meditation and sporadic use of psychedelics seems to result in lowered DMN activity.

Related: spectrum of cognitive states.